Comparison of Ramosetron with Palonosetron for Prevention of Postoperative Nausea and Vomiting in Patients Receiving Opioid-Based Intravenous Patient-Controlled Analgesia after Gynecological Laparoscopy

الملخص EN

We aimed to compare the effects of ramosetron and palonosetron in the prevention of postoperative nausea and vomiting (PONV) in patients that received opioid-based intravenous patient-controlled analgesia (IV-PCA) after gynecological laparoscopy.

We reviewed the electronic medical records of 755 adults.

Patients were classified into two groups, ramosetron (group R, n=589) versus palonosetron (group P, n=166).

Based on their confounding factors, 152 subjects in each group were selected after the implementation of propensity score matching.

The overall incidence of PONV at postoperative day (POD) 0 was lower in group R compared to group P (26.9% versus 36.8%; P=0.043).

The severity of nausea was lower in group R than in group P on postoperative day (POD) 0 (P=0.012).

Also, the complete responder proportion of patients was significantly higher in group R compared to that in group P on POD 0 (P=0.043).

In conclusion, ramosetron showed a greater efficacy in the prevention of postoperative nausea at POD 0 compared to palonosetron in patients after gynecological laparoscopy.