Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway
المؤلف
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
In recent years, pulmonary fibrosis caused by paraquat poisoning is still concerned.
However, no effective drugs have been developed yet to treat paraquat-induced pulmonary fibrosis.
The aim of our research is to investigate whether imrecoxib can inhibit paraquat-induced pulmonary fibrosis and its possible mechanism.
Methods.
Extraction of primary pulmonary fibrosis cells (PPF cells) in vitro by the method of trypsin digestion.
RT-qPCR and western blot were employed to measure the transcription level and protein expression of EMT related markers in paraquat-induced A549 cells.
MTT, wound-healing, and Transwell experiments were used to verify the effect of imrecoxib on the proliferation, migration, and invasion of PPF and HFL1 cells.
Results.
Firstly, our results confirmed that paraquat can induce EMT and activate the NF-κB/snail signal pathway in lung epithelial cell A549.
Furthermore, experimental results showed that imrecoxib could repress the proliferation, migration, and invasion of PPF and HFL1 cells.
Finally, our study found that imrecoxib can inhibit EMT of paraquat-induced A549 cells by the NF-κB/snail signal pathway.
Conclusion.
Imrecoxib can inhibit EMT of paraquat-induced A549 cells and alleviate paraquat-caused pulmonary fibrosis through the NF-κB/snail signal pathway.
Therefore, imrecoxib is a drug worthy of study in the treatment of paraquat-induced pulmonary fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Haihao. 2020. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Haihao. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1139516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Haihao. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر