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Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
In recent years, pulmonary fibrosis caused by paraquat poisoning is still concerned.
However, no effective drugs have been developed yet to treat paraquat-induced pulmonary fibrosis.
The aim of our research is to investigate whether imrecoxib can inhibit paraquat-induced pulmonary fibrosis and its possible mechanism.
Methods.
Extraction of primary pulmonary fibrosis cells (PPF cells) in vitro by the method of trypsin digestion.
RT-qPCR and western blot were employed to measure the transcription level and protein expression of EMT related markers in paraquat-induced A549 cells.
MTT, wound-healing, and Transwell experiments were used to verify the effect of imrecoxib on the proliferation, migration, and invasion of PPF and HFL1 cells.
Results.
Firstly, our results confirmed that paraquat can induce EMT and activate the NF-κB/snail signal pathway in lung epithelial cell A549.
Furthermore, experimental results showed that imrecoxib could repress the proliferation, migration, and invasion of PPF and HFL1 cells.
Finally, our study found that imrecoxib can inhibit EMT of paraquat-induced A549 cells by the NF-κB/snail signal pathway.
Conclusion.
Imrecoxib can inhibit EMT of paraquat-induced A549 cells and alleviate paraquat-caused pulmonary fibrosis through the NF-κB/snail signal pathway.
Therefore, imrecoxib is a drug worthy of study in the treatment of paraquat-induced pulmonary fibrosis.
American Psychological Association (APA)
Jin, Haihao. 2020. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139516
Modern Language Association (MLA)
Jin, Haihao. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1139516
American Medical Association (AMA)
Jin, Haihao. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κBSnail Signaling Pathway. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139516