Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice
المؤلفون المشاركون
Yessoufou, Akadiri
Nekoua, Magloire P.
Fachinan, Rufine
Fagninou, Adnette
Amoussa, Abdou Madjid
Adjagba, Marius
Lagnika, Latifou
Lalèyè, Anatole
Moutairou, Kabirou
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The mechanism of action of the antidiabetic capacity of Momordica charantia is still under investigation.
Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices of Momordica charantia on human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines.
In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation.
Under PHA stimulation, both juices potentiated plant-induced T cell proliferation.
However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation.
Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-γ production.
Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices.
Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable.
The saponins present in total juices were undetectable after filtration.
Moreover, both juices had appreciable antioxidant capacity.
Our study supports the type 1 antidiabetic effect of filtered fruit juice of M.
charantia which may be related to its immunosuppressive and T-helper 2 cell inducing capacities.
Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fachinan, Rufine& Fagninou, Adnette& Nekoua, Magloire P.& Amoussa, Abdou Madjid& Adjagba, Marius& Lagnika, Latifou…[et al.]. 2017. Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fachinan, Rufine…[et al.]. Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1139554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fachinan, Rufine& Fagninou, Adnette& Nekoua, Magloire P.& Amoussa, Abdou Madjid& Adjagba, Marius& Lagnika, Latifou…[et al.]. Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر