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Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice
Joint Authors
Yessoufou, Akadiri
Nekoua, Magloire P.
Fachinan, Rufine
Fagninou, Adnette
Amoussa, Abdou Madjid
Adjagba, Marius
Lagnika, Latifou
Lalèyè, Anatole
Moutairou, Kabirou
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The mechanism of action of the antidiabetic capacity of Momordica charantia is still under investigation.
Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices of Momordica charantia on human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines.
In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation.
Under PHA stimulation, both juices potentiated plant-induced T cell proliferation.
However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation.
Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-γ production.
Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices.
Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable.
The saponins present in total juices were undetectable after filtration.
Moreover, both juices had appreciable antioxidant capacity.
Our study supports the type 1 antidiabetic effect of filtered fruit juice of M.
charantia which may be related to its immunosuppressive and T-helper 2 cell inducing capacities.
Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.
American Psychological Association (APA)
Fachinan, Rufine& Fagninou, Adnette& Nekoua, Magloire P.& Amoussa, Abdou Madjid& Adjagba, Marius& Lagnika, Latifou…[et al.]. 2017. Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139554
Modern Language Association (MLA)
Fachinan, Rufine…[et al.]. Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1139554
American Medical Association (AMA)
Fachinan, Rufine& Fagninou, Adnette& Nekoua, Magloire P.& Amoussa, Abdou Madjid& Adjagba, Marius& Lagnika, Latifou…[et al.]. Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139554