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A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation
المؤلفون المشاركون
Zhou, Jin
Wang, Hongrui
Li, Licong
Sun, Hongji
Liu, Xiuling
Wang, Changyong
Liu, Jing
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Gamma-aminobutyric acid (GABA) is critical for proper neural network function and can activate astrocytes to induce neuronal excitability; however, the mechanism by which astrocytes transform inhibitory signaling to excitatory enhancement remains unclear.
Computational modeling can be a powerful tool to provide further understanding of how GABA-activated astrocytes modulate neuronal excitation.
In the present study, we implemented a biophysical neuronal network model to investigate the effects of astrocytes on excitatory pre- and postsynaptic terminals following exposure to increasing concentrations of external GABA.
The model completely describes the effects of GABA on astrocytes and excitatory presynaptic terminals within the framework of glutamatergic gliotransmission according to neurophysiological findings.
Utilizing this model, our results show that astrocytes can rapidly respond to incoming GABA by inducing Ca2+ oscillations and subsequent gliotransmitter glutamate release.
Elevation in GABA concentrations not only naturally decreases neuronal spikes but also enhances astrocytic glutamate release, which leads to an increase in astrocyte-mediated presynaptic release and postsynaptic slow inward currents.
Neuronal excitation induced by GABA-activated astrocytes partly counteracts the inhibitory effect of GABA.
Overall, the model helps to increase knowledge regarding the involvement of astrocytes in neuronal regulation using simulated bath perfusion of GABA, which may be useful for exploring the effects of GABA-type antiepileptic drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Licong& Zhou, Jin& Sun, Hongji& Liu, Jing& Wang, Hongrui& Liu, Xiuling…[et al.]. 2020. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1139627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Licong…[et al.]. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1139627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Licong& Zhou, Jin& Sun, Hongji& Liu, Jing& Wang, Hongrui& Liu, Xiuling…[et al.]. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1139627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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