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A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation
Joint Authors
Zhou, Jin
Wang, Hongrui
Li, Licong
Sun, Hongji
Liu, Xiuling
Wang, Changyong
Liu, Jing
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Gamma-aminobutyric acid (GABA) is critical for proper neural network function and can activate astrocytes to induce neuronal excitability; however, the mechanism by which astrocytes transform inhibitory signaling to excitatory enhancement remains unclear.
Computational modeling can be a powerful tool to provide further understanding of how GABA-activated astrocytes modulate neuronal excitation.
In the present study, we implemented a biophysical neuronal network model to investigate the effects of astrocytes on excitatory pre- and postsynaptic terminals following exposure to increasing concentrations of external GABA.
The model completely describes the effects of GABA on astrocytes and excitatory presynaptic terminals within the framework of glutamatergic gliotransmission according to neurophysiological findings.
Utilizing this model, our results show that astrocytes can rapidly respond to incoming GABA by inducing Ca2+ oscillations and subsequent gliotransmitter glutamate release.
Elevation in GABA concentrations not only naturally decreases neuronal spikes but also enhances astrocytic glutamate release, which leads to an increase in astrocyte-mediated presynaptic release and postsynaptic slow inward currents.
Neuronal excitation induced by GABA-activated astrocytes partly counteracts the inhibitory effect of GABA.
Overall, the model helps to increase knowledge regarding the involvement of astrocytes in neuronal regulation using simulated bath perfusion of GABA, which may be useful for exploring the effects of GABA-type antiepileptic drugs.
American Psychological Association (APA)
Li, Licong& Zhou, Jin& Sun, Hongji& Liu, Jing& Wang, Hongrui& Liu, Xiuling…[et al.]. 2020. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1139627
Modern Language Association (MLA)
Li, Licong…[et al.]. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1139627
American Medical Association (AMA)
Li, Licong& Zhou, Jin& Sun, Hongji& Liu, Jing& Wang, Hongrui& Liu, Xiuling…[et al.]. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1139627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139627