Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters
المؤلفون المشاركون
Chen, Wei
Wang, Yong
Li, Fei
Lin, Wei
Liang, Yong
Ma, Zhiwei
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-20
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
The objective of this study was to investigate the expression of telomere repeat binding factor 1 (TRF1) and TRF2 in prostate cancer and their relationships with clinicopathological features.
Methods.
In total 50 prostate cancer tissues and paired benign prostate hyperplasia tissues were analyzed.
The telomere-binding proteins TRF1 and TRF2 were measured using immunohistochemical method.
Correlation analyses were used to evaluate the association between immunohistochemical score and clinical parameters.
Results.
The expression of TRF1 was significantly higher in prostate cancer tissue than in benign prostate hyperplasia tissue (χ2 = 62.69, P<0.01).
Elevated levels of TRF2 were observed in both prostate cancer and benign prostate hyperplasia tissue (χ2 = 1.13, P=0.76).
TRF1 expression was significantly positively correlated with surgical capsular invasion (Spearman’s r=0.43, P=0.002), seminal vesicle invasion (Spearman’s r=0.35, P=0.01), lymph nodes metastases (Spearman’s r=0.41, P=0.003), total prostate specific antigen (r=0.61, P<0.05), and Gleason score (r=0.47, P=0.01).
However, there were no significant statistical differences between prostate volume (r=0.06, P=0.75) and age (r=0.14, P=0.09).
Conclusion.
Both TRF1 and TRF2 were overexpressed in prostate cancer.
There was no specificity of TRF2 in prostate cancer, while TRF1 may be associated with prostate cancer progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Wei& Wang, Yong& Li, Fei& Lin, Wei& Liang, Yong& Ma, Zhiwei. 2017. Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1139719
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Wei…[et al.]. Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1139719
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Wei& Wang, Yong& Li, Fei& Lin, Wei& Liang, Yong& Ma, Zhiwei. Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1139719
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139719
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر