Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters
Joint Authors
Chen, Wei
Wang, Yong
Li, Fei
Lin, Wei
Liang, Yong
Ma, Zhiwei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
The objective of this study was to investigate the expression of telomere repeat binding factor 1 (TRF1) and TRF2 in prostate cancer and their relationships with clinicopathological features.
Methods.
In total 50 prostate cancer tissues and paired benign prostate hyperplasia tissues were analyzed.
The telomere-binding proteins TRF1 and TRF2 were measured using immunohistochemical method.
Correlation analyses were used to evaluate the association between immunohistochemical score and clinical parameters.
Results.
The expression of TRF1 was significantly higher in prostate cancer tissue than in benign prostate hyperplasia tissue (χ2 = 62.69, P<0.01).
Elevated levels of TRF2 were observed in both prostate cancer and benign prostate hyperplasia tissue (χ2 = 1.13, P=0.76).
TRF1 expression was significantly positively correlated with surgical capsular invasion (Spearman’s r=0.43, P=0.002), seminal vesicle invasion (Spearman’s r=0.35, P=0.01), lymph nodes metastases (Spearman’s r=0.41, P=0.003), total prostate specific antigen (r=0.61, P<0.05), and Gleason score (r=0.47, P=0.01).
However, there were no significant statistical differences between prostate volume (r=0.06, P=0.75) and age (r=0.14, P=0.09).
Conclusion.
Both TRF1 and TRF2 were overexpressed in prostate cancer.
There was no specificity of TRF2 in prostate cancer, while TRF1 may be associated with prostate cancer progression.
American Psychological Association (APA)
Chen, Wei& Wang, Yong& Li, Fei& Lin, Wei& Liang, Yong& Ma, Zhiwei. 2017. Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1139719
Modern Language Association (MLA)
Chen, Wei…[et al.]. Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1139719
American Medical Association (AMA)
Chen, Wei& Wang, Yong& Li, Fei& Lin, Wei& Liang, Yong& Ma, Zhiwei. Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1139719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139719