Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate
المؤلفون المشاركون
Alves, Carlos R.
Ferreira, Vitor F.
Cysne-Finkelstein, Léa
Oliveira, Luiz Filipe Gonçalves
Souza-Silva, Franklin
Rabelo, Kíssila
Amorim, Juliana Fernandes
Azevedo, Adriana de Souza
Bourguignon, Saulo Cabral
Paes, Marciano Viana
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy.
Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite.
Oxiranes derived from naphthoquinones now being assayed are promising drugs for the treatment of this group of diseases.
The predicted pharmacokinetic properties and toxicological profiles of epoxy-α-lapachone and epoxymethoxy-lawsone have now been compared to those of meglumine antimoniate, and histological changes induced by these drugs in noninfected BALB/c mice tissues are described.
Effects of these compounds on liver, kidney, lung, heart, and cerebral tissues of healthy mice were examined.
The data presented show that both these oxiranes and meglumine antimoniate induce changes in all BALB/c mice tissues, with the lung, heart, and brain being the most affected.
Epoxymethoxy-lawsone was the most toxic to lung tissue, while most severe damage was caused in the heart by epoxy-α-lapachone.
Meglumine antimoniate caused mild-to-moderate changes in heart and lung tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Luiz Filipe Gonçalves& Souza-Silva, Franklin& Cysne-Finkelstein, Léa& Rabelo, Kíssila& Amorim, Juliana Fernandes& Azevedo, Adriana de Souza…[et al.]. 2017. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Luiz Filipe Gonçalves…[et al.]. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Luiz Filipe Gonçalves& Souza-Silva, Franklin& Cysne-Finkelstein, Léa& Rabelo, Kíssila& Amorim, Juliana Fernandes& Azevedo, Adriana de Souza…[et al.]. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر