Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate
Joint Authors
Alves, Carlos R.
Ferreira, Vitor F.
Cysne-Finkelstein, Léa
Oliveira, Luiz Filipe Gonçalves
Souza-Silva, Franklin
Rabelo, Kíssila
Amorim, Juliana Fernandes
Azevedo, Adriana de Souza
Bourguignon, Saulo Cabral
Paes, Marciano Viana
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy.
Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite.
Oxiranes derived from naphthoquinones now being assayed are promising drugs for the treatment of this group of diseases.
The predicted pharmacokinetic properties and toxicological profiles of epoxy-α-lapachone and epoxymethoxy-lawsone have now been compared to those of meglumine antimoniate, and histological changes induced by these drugs in noninfected BALB/c mice tissues are described.
Effects of these compounds on liver, kidney, lung, heart, and cerebral tissues of healthy mice were examined.
The data presented show that both these oxiranes and meglumine antimoniate induce changes in all BALB/c mice tissues, with the lung, heart, and brain being the most affected.
Epoxymethoxy-lawsone was the most toxic to lung tissue, while most severe damage was caused in the heart by epoxy-α-lapachone.
Meglumine antimoniate caused mild-to-moderate changes in heart and lung tissues.
American Psychological Association (APA)
Oliveira, Luiz Filipe Gonçalves& Souza-Silva, Franklin& Cysne-Finkelstein, Léa& Rabelo, Kíssila& Amorim, Juliana Fernandes& Azevedo, Adriana de Souza…[et al.]. 2017. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139736
Modern Language Association (MLA)
Oliveira, Luiz Filipe Gonçalves…[et al.]. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139736
American Medical Association (AMA)
Oliveira, Luiz Filipe Gonçalves& Souza-Silva, Franklin& Cysne-Finkelstein, Léa& Rabelo, Kíssila& Amorim, Juliana Fernandes& Azevedo, Adriana de Souza…[et al.]. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139736