Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate

Joint Authors

Alves, Carlos R.
Ferreira, Vitor F.
Cysne-Finkelstein, Léa
Oliveira, Luiz Filipe Gonçalves
Souza-Silva, Franklin
Rabelo, Kíssila
Amorim, Juliana Fernandes
Azevedo, Adriana de Souza
Bourguignon, Saulo Cabral
Paes, Marciano Viana

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-07-17

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy.

Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite.

Oxiranes derived from naphthoquinones now being assayed are promising drugs for the treatment of this group of diseases.

The predicted pharmacokinetic properties and toxicological profiles of epoxy-α-lapachone and epoxymethoxy-lawsone have now been compared to those of meglumine antimoniate, and histological changes induced by these drugs in noninfected BALB/c mice tissues are described.

Effects of these compounds on liver, kidney, lung, heart, and cerebral tissues of healthy mice were examined.

The data presented show that both these oxiranes and meglumine antimoniate induce changes in all BALB/c mice tissues, with the lung, heart, and brain being the most affected.

Epoxymethoxy-lawsone was the most toxic to lung tissue, while most severe damage was caused in the heart by epoxy-α-lapachone.

Meglumine antimoniate caused mild-to-moderate changes in heart and lung tissues.

American Psychological Association (APA)

Oliveira, Luiz Filipe Gonçalves& Souza-Silva, Franklin& Cysne-Finkelstein, Léa& Rabelo, Kíssila& Amorim, Juliana Fernandes& Azevedo, Adriana de Souza…[et al.]. 2017. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139736

Modern Language Association (MLA)

Oliveira, Luiz Filipe Gonçalves…[et al.]. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139736

American Medical Association (AMA)

Oliveira, Luiz Filipe Gonçalves& Souza-Silva, Franklin& Cysne-Finkelstein, Léa& Rabelo, Kíssila& Amorim, Juliana Fernandes& Azevedo, Adriana de Souza…[et al.]. Evidence for Tissue Toxicity in BALBc Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139736

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1139736