Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway
المؤلفون المشاركون
Gao, Lu
Shi, Jumei
Chang, Gaomei
Xiao, Wenqin
Xu, Zhijian
Yu, Dandan
Li, Bo
Zhang, Yong
Sun, Xi
Xie, Yongsheng
Chang, Shuaikang
Chen, Gege
Hu, Liangning
Xie, Bingqian
Dai, Bojie
Zhu, Weiliang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Pterostilbene is a natural 3,5-dimethoxy analog of trans-resveratrol that has been reported to have antitumor, antioxidant, and anti-inflammatory effects.
T-cell leukemia/lymphoma is one of the more aggressive yet uncommon non-Hodgkin lymphomas.
Although there has been increasing research into T-cell leukemia/lymphoma, the molecular mechanisms of the antitumor effects of pterostilbene against this malignancy are still largely unknown.
The aim of this study is to confirm the effects of pterostilbene in T-cell leukemia/lymphoma.
Jurkat and Hut-78 cells treated with pterostilbene were evaluated for cell proliferation using Cell Counting Kit-8, and apoptosis, cell cycle progression, reactive oxygen species generation, and mitochondrial membrane potential were analyzed using flow cytometry.
The level of protein expression was detected by western blot.
The results demonstrated that pterostilbene significantly inhibited the growth of T-cell leukemia/lymphoma cell lines in vitro and induced apoptosis in a dose- and time-dependent manner.
Moreover, pterostilbene treatment markedly induced S-phase cell cycle arrest, which was accompanied by downregulation of cdc25A, cyclin A2, and CDK2.
Pterostilbene also induced the generation of reactive oxygen species and the loss of mitochondrial membrane potential and inhibited ERK1/2 phosphorylation.
Taken together, our study demonstrated the potential of pterostilbene to be an effective treatment for T-cell leukemia/lymphoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Gaomei& Xiao, Wenqin& Xu, Zhijian& Yu, Dandan& Li, Bo& Zhang, Yong…[et al.]. 2017. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Gaomei…[et al.]. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Gaomei& Xiao, Wenqin& Xu, Zhijian& Yu, Dandan& Li, Bo& Zhang, Yong…[et al.]. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر