Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway
Joint Authors
Gao, Lu
Shi, Jumei
Chang, Gaomei
Xiao, Wenqin
Xu, Zhijian
Yu, Dandan
Li, Bo
Zhang, Yong
Sun, Xi
Xie, Yongsheng
Chang, Shuaikang
Chen, Gege
Hu, Liangning
Xie, Bingqian
Dai, Bojie
Zhu, Weiliang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pterostilbene is a natural 3,5-dimethoxy analog of trans-resveratrol that has been reported to have antitumor, antioxidant, and anti-inflammatory effects.
T-cell leukemia/lymphoma is one of the more aggressive yet uncommon non-Hodgkin lymphomas.
Although there has been increasing research into T-cell leukemia/lymphoma, the molecular mechanisms of the antitumor effects of pterostilbene against this malignancy are still largely unknown.
The aim of this study is to confirm the effects of pterostilbene in T-cell leukemia/lymphoma.
Jurkat and Hut-78 cells treated with pterostilbene were evaluated for cell proliferation using Cell Counting Kit-8, and apoptosis, cell cycle progression, reactive oxygen species generation, and mitochondrial membrane potential were analyzed using flow cytometry.
The level of protein expression was detected by western blot.
The results demonstrated that pterostilbene significantly inhibited the growth of T-cell leukemia/lymphoma cell lines in vitro and induced apoptosis in a dose- and time-dependent manner.
Moreover, pterostilbene treatment markedly induced S-phase cell cycle arrest, which was accompanied by downregulation of cdc25A, cyclin A2, and CDK2.
Pterostilbene also induced the generation of reactive oxygen species and the loss of mitochondrial membrane potential and inhibited ERK1/2 phosphorylation.
Taken together, our study demonstrated the potential of pterostilbene to be an effective treatment for T-cell leukemia/lymphoma.
American Psychological Association (APA)
Chang, Gaomei& Xiao, Wenqin& Xu, Zhijian& Yu, Dandan& Li, Bo& Zhang, Yong…[et al.]. 2017. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139748
Modern Language Association (MLA)
Chang, Gaomei…[et al.]. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139748
American Medical Association (AMA)
Chang, Gaomei& Xiao, Wenqin& Xu, Zhijian& Yu, Dandan& Li, Bo& Zhang, Yong…[et al.]. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell LeukemiaLymphoma by Suppressing the ERK12 Pathway. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139748