Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection
المؤلفون المشاركون
Kalkum, Markus
Ramakrishna, Chandran
Golub, Mari S.
Chiang, Abby
Hong, Teresa
Cantin, Edouard
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life.
We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses.
We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone.
Anxiety levels were high in HSV-infected PBS and ACV-treated mice compared to mice treated with ACV + IVIG, consistent with reports implicating inflammation in anxiety induced by lipopolysaccharide (LPS) or stress.
Female, but not male, PBS-treated mice were cognitively impaired, and unexpectedly, ACV was protective, while the inclusion of IVIG surprisingly antagonized ACV’s beneficial effects.
Distinct serum proteomic profiles were observed for male and female mice, and the antagonistic effects of ACV and IVIG on behavior were paralleled by similar changes in the serum proteome of ACV- and ACV + IVIG-treated mice.
We conclude that inflammation and other factors mediate HSV-induced behavioral impairments and that the effects of ACV and IVIG on behavior involve novel mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramakrishna, Chandran& Golub, Mari S.& Chiang, Abby& Hong, Teresa& Kalkum, Markus& Cantin, Edouard. 2017. Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramakrishna, Chandran…[et al.]. Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection. Behavioural Neurology No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1139776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramakrishna, Chandran& Golub, Mari S.& Chiang, Abby& Hong, Teresa& Kalkum, Markus& Cantin, Edouard. Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر