Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection
Joint Authors
Kalkum, Markus
Ramakrishna, Chandran
Golub, Mari S.
Chiang, Abby
Hong, Teresa
Cantin, Edouard
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life.
We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses.
We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone.
Anxiety levels were high in HSV-infected PBS and ACV-treated mice compared to mice treated with ACV + IVIG, consistent with reports implicating inflammation in anxiety induced by lipopolysaccharide (LPS) or stress.
Female, but not male, PBS-treated mice were cognitively impaired, and unexpectedly, ACV was protective, while the inclusion of IVIG surprisingly antagonized ACV’s beneficial effects.
Distinct serum proteomic profiles were observed for male and female mice, and the antagonistic effects of ACV and IVIG on behavior were paralleled by similar changes in the serum proteome of ACV- and ACV + IVIG-treated mice.
We conclude that inflammation and other factors mediate HSV-induced behavioral impairments and that the effects of ACV and IVIG on behavior involve novel mechanisms.
American Psychological Association (APA)
Ramakrishna, Chandran& Golub, Mari S.& Chiang, Abby& Hong, Teresa& Kalkum, Markus& Cantin, Edouard. 2017. Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139776
Modern Language Association (MLA)
Ramakrishna, Chandran…[et al.]. Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection. Behavioural Neurology No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1139776
American Medical Association (AMA)
Ramakrishna, Chandran& Golub, Mari S.& Chiang, Abby& Hong, Teresa& Kalkum, Markus& Cantin, Edouard. Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139776