Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study
المؤلفون المشاركون
Xu, Yun
Zhang, Bing
Qing, Zhao
Li, Weiping
Nedelska, Zuzana
Wu, Wenbo
Wang, Fangfang
Liu, Renyuan
Zhao, Hui
Chen, Weibo
Chan, Queenie
Zhu, Bin
Hort, Jakub
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Impairment of spatial navigation (SN) skills is one of the features of the Alzheimer’s disease (AD) already at the stage of mild cognitive impairment (MCI).
We used a computer-based battery of spatial navigation tests to measure the SN performance in 22 MCI patients as well as 21 normal controls (NC).
In order to evaluate intrinsic activity in the subcortical regions that may play a role in SN, we measured ALFF, fALFF, and ReHo derived within 14 subcortical regions.
We observed reductions of intrinsic activity in MCI patients.
We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F=4.44, p=0.05), pallidum (F=8.97, p=0.005), and thalamus (F=5.95, p=0.02), which were negative in NC (right hippocampus, r=−0.49; right pallidum, r=−0.50; right thalamus, r=−0.45; all p<0.05) but absent in MCI (right hippocampus, r=0.21; right pallidum, r=0.32; right thalamus r=0.28; all p>0.2).
These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia.
This trial is registered with ChiCTR-BRC-17011316.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qing, Zhao& Li, Weiping& Nedelska, Zuzana& Wu, Wenbo& Wang, Fangfang& Liu, Renyuan…[et al.]. 2017. Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139783
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qing, Zhao…[et al.]. Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study. Behavioural Neurology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139783
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qing, Zhao& Li, Weiping& Nedelska, Zuzana& Wu, Wenbo& Wang, Fangfang& Liu, Renyuan…[et al.]. Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139783
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139783
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر