Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study
Joint Authors
Xu, Yun
Zhang, Bing
Qing, Zhao
Li, Weiping
Nedelska, Zuzana
Wu, Wenbo
Wang, Fangfang
Liu, Renyuan
Zhao, Hui
Chen, Weibo
Chan, Queenie
Zhu, Bin
Hort, Jakub
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Impairment of spatial navigation (SN) skills is one of the features of the Alzheimer’s disease (AD) already at the stage of mild cognitive impairment (MCI).
We used a computer-based battery of spatial navigation tests to measure the SN performance in 22 MCI patients as well as 21 normal controls (NC).
In order to evaluate intrinsic activity in the subcortical regions that may play a role in SN, we measured ALFF, fALFF, and ReHo derived within 14 subcortical regions.
We observed reductions of intrinsic activity in MCI patients.
We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F=4.44, p=0.05), pallidum (F=8.97, p=0.005), and thalamus (F=5.95, p=0.02), which were negative in NC (right hippocampus, r=−0.49; right pallidum, r=−0.50; right thalamus, r=−0.45; all p<0.05) but absent in MCI (right hippocampus, r=0.21; right pallidum, r=0.32; right thalamus r=0.28; all p>0.2).
These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia.
This trial is registered with ChiCTR-BRC-17011316.
American Psychological Association (APA)
Qing, Zhao& Li, Weiping& Nedelska, Zuzana& Wu, Wenbo& Wang, Fangfang& Liu, Renyuan…[et al.]. 2017. Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139783
Modern Language Association (MLA)
Qing, Zhao…[et al.]. Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study. Behavioural Neurology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139783
American Medical Association (AMA)
Qing, Zhao& Li, Weiping& Nedelska, Zuzana& Wu, Wenbo& Wang, Fangfang& Liu, Renyuan…[et al.]. Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139783