In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase

المؤلفون المشاركون

Shi, Zhi-Long
Liu, Yi-Dan
Yuan, Yun-Yun
Song, Da
Qi, Mei-Feng
Yang, Xu-Juan
Wang, Ping
Li, Xiao-Ying
Shang, Jian-Hua
Yang, Zhao-Xiang

المصدر

Biochemistry Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-01-10

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء

الملخص EN

Norathyriol is a metabolite of mangiferin.

Mangiferin has been reported to inhibit α-glucosidase.

To the best of our knowledge, no study has been conducted to determine or compare those two compounds on inhibiting α-glucosidase in vitro and in vivo by far.

In this study, we determined the inhibitory activity of norathyriol and mangiferin on α-glucosidase in vitro and evaluated their antidiabetic effect in diabetic mice.

The results showed that norathyriol inhibited α-glucosidase in a noncompetitive manner with an IC50 value of 3.12 μM, which is more potent than mangiferin (IC50 = 358.54 μM) and positive drug acarbose (IC50 = 479.2 μM) in the zymological experiment.

Both of norathyriol and mangiferin caused significant (p<0.05) reduction in fasting blood glucose and the blood glucose levels at two hours after carbohydrate loading and it was interesting that mangiferin and norathyriol can make the decline of the blood glucose earlier than other groups ever including normal group in the starch tolerance test.

However, norathyriol and mangiferin did not significantly influence carbohydrate absorption in the glucose tolerance test.

Therefore, the antidiabetic effects of norathyriol and mangiferin might be associated with α-glucosidase, and norathyriol was more potent than mangiferin.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Shi, Zhi-Long& Liu, Yi-Dan& Yuan, Yun-Yun& Song, Da& Qi, Mei-Feng& Yang, Xu-Juan…[et al.]. 2017. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochemistry Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139795

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Shi, Zhi-Long…[et al.]. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochemistry Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139795

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Shi, Zhi-Long& Liu, Yi-Dan& Yuan, Yun-Yun& Song, Da& Qi, Mei-Feng& Yang, Xu-Juan…[et al.]. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochemistry Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139795

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1139795