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In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase
Joint Authors
Shi, Zhi-Long
Liu, Yi-Dan
Yuan, Yun-Yun
Song, Da
Qi, Mei-Feng
Yang, Xu-Juan
Wang, Ping
Li, Xiao-Ying
Shang, Jian-Hua
Yang, Zhao-Xiang
Source
Biochemistry Research International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Norathyriol is a metabolite of mangiferin.
Mangiferin has been reported to inhibit α-glucosidase.
To the best of our knowledge, no study has been conducted to determine or compare those two compounds on inhibiting α-glucosidase in vitro and in vivo by far.
In this study, we determined the inhibitory activity of norathyriol and mangiferin on α-glucosidase in vitro and evaluated their antidiabetic effect in diabetic mice.
The results showed that norathyriol inhibited α-glucosidase in a noncompetitive manner with an IC50 value of 3.12 μM, which is more potent than mangiferin (IC50 = 358.54 μM) and positive drug acarbose (IC50 = 479.2 μM) in the zymological experiment.
Both of norathyriol and mangiferin caused significant (p<0.05) reduction in fasting blood glucose and the blood glucose levels at two hours after carbohydrate loading and it was interesting that mangiferin and norathyriol can make the decline of the blood glucose earlier than other groups ever including normal group in the starch tolerance test.
However, norathyriol and mangiferin did not significantly influence carbohydrate absorption in the glucose tolerance test.
Therefore, the antidiabetic effects of norathyriol and mangiferin might be associated with α-glucosidase, and norathyriol was more potent than mangiferin.
American Psychological Association (APA)
Shi, Zhi-Long& Liu, Yi-Dan& Yuan, Yun-Yun& Song, Da& Qi, Mei-Feng& Yang, Xu-Juan…[et al.]. 2017. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochemistry Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139795
Modern Language Association (MLA)
Shi, Zhi-Long…[et al.]. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochemistry Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139795
American Medical Association (AMA)
Shi, Zhi-Long& Liu, Yi-Dan& Yuan, Yun-Yun& Song, Da& Qi, Mei-Feng& Yang, Xu-Juan…[et al.]. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochemistry Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139795