Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity
المؤلفون المشاركون
López-Alarcón, Mardia
Maldonado-Hernández, Jorge
Saldaña-Dávila, Gabriela E.
Piña-Aguero, Mónica I.
Núñez-García, Benjamín A.
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity.
Materials and Methods.
Ninety-four adolescents from two previous studies conducted and published by our crew were included.
Study subjects were stratified in three groups: normal weight (n=18), obesity (n=34), and obesity + HS (n=42).
The presence of HS was defined when ALT/AST ratio was <1.
Ceramides subspecies (C14:0, C16:0, C18:0, C24:0, and C24:1) were determined by LC/MS.
Results.
All ceramides correlated directly with ALT levels and inversely with ALT/AST ratio; the strongest correlation was observed among C14:0 ceramide (r=0.41 and r=-0.54, resp.; P<0.001).
Furthermore, significant correlations were observed between cholesterol and all ceramides except for C24:1 ceramide.
Interestingly ceramides C14:0, C18:0, and C24:1 correlated directly with both fasting insulin and HOMA-IR index.
For assessing HS, a cut-off point of 10.3 nmol/L for C14:0 ceramide reported a sensitivity of 92.7% and a specificity of 73.5% when normal weight and obesity groups (n=52) were compared against obesity + HS group (n=42).
Positive and negative predictive values were 77.5% and 90.2%, respectively.
Conclusions.
Plasma ceramides are closely associated with hepatic steatosis in adolescents.
C14:0 ceramide could be a novel biomarker of HS independently of obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maldonado-Hernández, Jorge& Saldaña-Dávila, Gabriela E.& Piña-Aguero, Mónica I.& Núñez-García, Benjamín A.& López-Alarcón, Mardia. 2017. Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maldonado-Hernández, Jorge…[et al.]. Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1141401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maldonado-Hernández, Jorge& Saldaña-Dávila, Gabriela E.& Piña-Aguero, Mónica I.& Núñez-García, Benjamín A.& López-Alarcón, Mardia. Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر