Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity
Joint Authors
López-Alarcón, Mardia
Maldonado-Hernández, Jorge
Saldaña-Dávila, Gabriela E.
Piña-Aguero, Mónica I.
Núñez-García, Benjamín A.
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity.
Materials and Methods.
Ninety-four adolescents from two previous studies conducted and published by our crew were included.
Study subjects were stratified in three groups: normal weight (n=18), obesity (n=34), and obesity + HS (n=42).
The presence of HS was defined when ALT/AST ratio was <1.
Ceramides subspecies (C14:0, C16:0, C18:0, C24:0, and C24:1) were determined by LC/MS.
Results.
All ceramides correlated directly with ALT levels and inversely with ALT/AST ratio; the strongest correlation was observed among C14:0 ceramide (r=0.41 and r=-0.54, resp.; P<0.001).
Furthermore, significant correlations were observed between cholesterol and all ceramides except for C24:1 ceramide.
Interestingly ceramides C14:0, C18:0, and C24:1 correlated directly with both fasting insulin and HOMA-IR index.
For assessing HS, a cut-off point of 10.3 nmol/L for C14:0 ceramide reported a sensitivity of 92.7% and a specificity of 73.5% when normal weight and obesity groups (n=52) were compared against obesity + HS group (n=42).
Positive and negative predictive values were 77.5% and 90.2%, respectively.
Conclusions.
Plasma ceramides are closely associated with hepatic steatosis in adolescents.
C14:0 ceramide could be a novel biomarker of HS independently of obesity.
American Psychological Association (APA)
Maldonado-Hernández, Jorge& Saldaña-Dávila, Gabriela E.& Piña-Aguero, Mónica I.& Núñez-García, Benjamín A.& López-Alarcón, Mardia. 2017. Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141401
Modern Language Association (MLA)
Maldonado-Hernández, Jorge…[et al.]. Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1141401
American Medical Association (AMA)
Maldonado-Hernández, Jorge& Saldaña-Dávila, Gabriela E.& Piña-Aguero, Mónica I.& Núñez-García, Benjamín A.& López-Alarcón, Mardia. Association between Plasmatic Ceramides Profile and ASTALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141401