Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
المؤلفون المشاركون
Kimura, Takefumi
Maruyama, Masafumi
Tanaka, Naoki
Kubota, Daisuke
Miyajima, Masayuki
Tokutake, Koujiro
Imai, Ryujiro
Fujisawa, Toru
Mori, Hiromitsu
Matsuda, Yoshiaki
Wada, Shuichi
Horiuchi, Akira
Kiyosawa, Kendo
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
A new agent, potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer advantages over conventional H.
pylori eradication therapies.
We aimed to compare the eradication rate between VPZ-based treatment and PPI-based one.
Methods.
This randomized controlled trial was designed to assign 141 patients with H.
pylori-positive gastritis to VPZ group (VPZ 20 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days) or PPI group (rabeprazole 20 mg or lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days).
Primary endpoints were eradication rates and adverse events.
Results.
Seventy of 72 patients in VPZ group and 63 of 69 patients in PPI group completed the treatment after 7 days.
The eradication rate was significantly higher in VPZ group than PPI group by intention-to-treat analysis (95.8% versus 69.6%, P=0.00003, 95% confidence interval [CI] 88.3-99.1% versus 57.3-80.1%) and per-protocol analysis (95.7% versus 71.4%, P=0.0002, 95% CI 88.0-99.1% versus 58.7-82.1%).
The incidence of adverse events was not different between the groups (26.3% in VPZ group versus 37.7% in PPI group, P=0.15).
Conclusion.
VPZ-based regimen is more useful than that PPI-based regimen as a first-line H.
pylori eradication therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maruyama, Masafumi& Tanaka, Naoki& Kubota, Daisuke& Miyajima, Masayuki& Kimura, Takefumi& Tokutake, Koujiro…[et al.]. 2017. Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maruyama, Masafumi…[et al.]. Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1141415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maruyama, Masafumi& Tanaka, Naoki& Kubota, Daisuke& Miyajima, Masayuki& Kimura, Takefumi& Tokutake, Koujiro…[et al.]. Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر