Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial

Abstract EN

Background.

A new agent, potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer advantages over conventional H.

pylori eradication therapies.

We aimed to compare the eradication rate between VPZ-based treatment and PPI-based one.

Methods.

This randomized controlled trial was designed to assign 141 patients with H.

pylori-positive gastritis to VPZ group (VPZ 20 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days) or PPI group (rabeprazole 20 mg or lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days).

Primary endpoints were eradication rates and adverse events.

Results.

Seventy of 72 patients in VPZ group and 63 of 69 patients in PPI group completed the treatment after 7 days.

The eradication rate was significantly higher in VPZ group than PPI group by intention-to-treat analysis (95.8% versus 69.6%, P=0.00003, 95% confidence interval [CI] 88.3-99.1% versus 57.3-80.1%) and per-protocol analysis (95.7% versus 71.4%, P=0.0002, 95% CI 88.0-99.1% versus 58.7-82.1%).

The incidence of adverse events was not different between the groups (26.3% in VPZ group versus 37.7% in PPI group, P=0.15).

Conclusion.

VPZ-based regimen is more useful than that PPI-based regimen as a first-line H.

pylori eradication therapy.