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In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials
المؤلفون المشاركون
Owusu, Enid
Newman, Mercy Jemima
Addo, Kwesi K.
Addo, Phyllis
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance an unavoidable one.
This is as a result of drug misuse by health personnel and patients’ noncompliance to treatment regimen.
Monitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer disease.
This study therefore investigated the inhibitory activity of some antibiotics against isolates of Mycobacterium ulcerans.
Methods.
Activity of eight antibiotics was tested against twelve M.
ulcerans isolates (2 reference strains and 10 clinical isolates).
The anti-M.
ulcerans activities were determined by the agar dilution method and the minimum inhibitory concentrations (MICs) were determined by the agar proportion method.
Results.
All antimicrobials investigated had activity against M.
ulcerans isolates tested.
The MICs ranged from 0.16 μg/mL to 2.5 μg/mL.
Azithromycin recorded the highest inhibitory activity at a mean MIC of 0.39 μg/mL, whilst clofazimine a second-line antileprosy drug, recorded the lowest at a mean MIC of 2.19 μg/mL.
Among the four antituberculosis drugs, rifampicin had the highest activity with a mean MIC of 0.81 μg/mL.
Conclusion.
Azithromycin could be considered as a lucrative alternative to existing treatment methods for inhibiting M.
ulcerans in Ghana.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Owusu, Enid& Newman, Mercy Jemima& Addo, Kwesi K.& Addo, Phyllis. 2017. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Owusu, Enid…[et al.]. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1141578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Owusu, Enid& Newman, Mercy Jemima& Addo, Kwesi K.& Addo, Phyllis. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141578
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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