In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials
Joint Authors
Owusu, Enid
Newman, Mercy Jemima
Addo, Kwesi K.
Addo, Phyllis
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance an unavoidable one.
This is as a result of drug misuse by health personnel and patients’ noncompliance to treatment regimen.
Monitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer disease.
This study therefore investigated the inhibitory activity of some antibiotics against isolates of Mycobacterium ulcerans.
Methods.
Activity of eight antibiotics was tested against twelve M.
ulcerans isolates (2 reference strains and 10 clinical isolates).
The anti-M.
ulcerans activities were determined by the agar dilution method and the minimum inhibitory concentrations (MICs) were determined by the agar proportion method.
Results.
All antimicrobials investigated had activity against M.
ulcerans isolates tested.
The MICs ranged from 0.16 μg/mL to 2.5 μg/mL.
Azithromycin recorded the highest inhibitory activity at a mean MIC of 0.39 μg/mL, whilst clofazimine a second-line antileprosy drug, recorded the lowest at a mean MIC of 2.19 μg/mL.
Among the four antituberculosis drugs, rifampicin had the highest activity with a mean MIC of 0.81 μg/mL.
Conclusion.
Azithromycin could be considered as a lucrative alternative to existing treatment methods for inhibiting M.
ulcerans in Ghana.
American Psychological Association (APA)
Owusu, Enid& Newman, Mercy Jemima& Addo, Kwesi K.& Addo, Phyllis. 2017. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141578
Modern Language Association (MLA)
Owusu, Enid…[et al.]. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1141578
American Medical Association (AMA)
Owusu, Enid& Newman, Mercy Jemima& Addo, Kwesi K.& Addo, Phyllis. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141578