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Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China
المؤلفون المشاركون
Wang, Long-Bai
Chen, Qiu-Yong
Wu, Xue-Min
Wang, Cheng-Yan
Chen, Ru-Jing
Zhou, Lun-Jiang
Yan, Shan
Che, Yong-liang
Liu, Yu-tao
Xiu, Jin-sheng
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The outbreaks of pseudorabies have been frequently reported in Bartha-K61-vaccinated farms in China since 2011.
To study the pathogenicity and evolution of the circulating pseudorabies viruses in Fujian Province, mainland China, we isolated and sequenced the whole genome of a wild-type pseudorabies virus strain named “FJ-2012.” We then conducted a few downstream bioinformatics analyses including phylogenetic analysis and pathogenic analysis and used the virus to infect 6 pseudorabies virus-free piglets.
FJ-2012-infected piglets developed symptoms like high body temperature and central nervous system disorders and had high mortality rate.
In addition, we identified typical micropathological changes such as multiple gross lesions in infected piglets through pathological analysis and conclude that the FJ-2012 genome is significantly different from known pseudorabies viruses, in which insertions, deletions, and substitutions are observed in multiple immune and virulence genes.
In summary, this study shed lights on the molecular basis of the prevalence and pathology of the pseudorabies virus strain FJ-2012.
The genome of FJ-2012 could be used as a reference to study the evolution of pseudorabies viruses, which is critical to the vaccine development of new emerging pseudorabies viruses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xue-Min& Chen, Qiu-Yong& Chen, Ru-Jing& Che, Yong-liang& Wang, Long-Bai& Wang, Cheng-Yan…[et al.]. 2017. Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xue-Min…[et al.]. Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xue-Min& Chen, Qiu-Yong& Chen, Ru-Jing& Che, Yong-liang& Wang, Long-Bai& Wang, Cheng-Yan…[et al.]. Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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