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Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China
Joint Authors
Wang, Long-Bai
Chen, Qiu-Yong
Wu, Xue-Min
Wang, Cheng-Yan
Chen, Ru-Jing
Zhou, Lun-Jiang
Yan, Shan
Che, Yong-liang
Liu, Yu-tao
Xiu, Jin-sheng
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The outbreaks of pseudorabies have been frequently reported in Bartha-K61-vaccinated farms in China since 2011.
To study the pathogenicity and evolution of the circulating pseudorabies viruses in Fujian Province, mainland China, we isolated and sequenced the whole genome of a wild-type pseudorabies virus strain named “FJ-2012.” We then conducted a few downstream bioinformatics analyses including phylogenetic analysis and pathogenic analysis and used the virus to infect 6 pseudorabies virus-free piglets.
FJ-2012-infected piglets developed symptoms like high body temperature and central nervous system disorders and had high mortality rate.
In addition, we identified typical micropathological changes such as multiple gross lesions in infected piglets through pathological analysis and conclude that the FJ-2012 genome is significantly different from known pseudorabies viruses, in which insertions, deletions, and substitutions are observed in multiple immune and virulence genes.
In summary, this study shed lights on the molecular basis of the prevalence and pathology of the pseudorabies virus strain FJ-2012.
The genome of FJ-2012 could be used as a reference to study the evolution of pseudorabies viruses, which is critical to the vaccine development of new emerging pseudorabies viruses.
American Psychological Association (APA)
Wu, Xue-Min& Chen, Qiu-Yong& Chen, Ru-Jing& Che, Yong-liang& Wang, Long-Bai& Wang, Cheng-Yan…[et al.]. 2017. Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141611
Modern Language Association (MLA)
Wu, Xue-Min…[et al.]. Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141611
American Medical Association (AMA)
Wu, Xue-Min& Chen, Qiu-Yong& Chen, Ru-Jing& Che, Yong-liang& Wang, Long-Bai& Wang, Cheng-Yan…[et al.]. Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141611