MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI
المؤلفون المشاركون
Chang, Kiyuk
Hong, Kwan-Su
Park, Cheongsoo
Park, Eun-Hye
Kang, Jongeun
Zaheer, Javeria
Lee, Hee Gu
Lee, Chul-Ho
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We evaluated the relationship between myocardial infarct size and inflammatory response using cardiac magnetic resonance imaging (CMR) in an acute myocardial infarction (AMI) mouse model.
Myocardial infarction (MI) was induced in 14 mice by permanent ligation of the left anterior descending artery.
Late gadolinium enhancement (LGE), manganese-enhanced MRI (MEMRI), and magnetofluorescent nanoparticle MRI (MNP-MRI) were performed 1, 2, and 3 days after MI, respectively.
The size of the enhanced lesion was quantitatively determined using Otsu’s thresholding method in area-based and sector-based approaches and was compared statistically.
Linear correlation between the enhanced lesion sizes was evaluated by Pearson’s correlation coefficients.
Differences were compared using Bland-Altman analysis.
The size of the inflammatory area determined by MNP-MRI (57.1 ± 10.1%) was significantly larger than that of the infarct area measured by LGE (40.8 ± 11.7%, P<0.0001) and MEMRI (44.1 ± 14.9%, P<0.0001).
There were significant correlations between the sizes of the infarct and inflammatory lesions (MNP-MRI versus LGE: r=0.3418, P=0.0099; MNP-MRI versus MEMRI: r=0.4764, P=0.0002).
MNP-MRI provides information about inflammatory responses in a mouse model of AMI.
Thus, MNP-MRI associated with LGE and MEMRI may play an important role in monitoring the disease progression in MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Cheongsoo& Park, Eun-Hye& Kang, Jongeun& Zaheer, Javeria& Lee, Hee Gu& Lee, Chul-Ho…[et al.]. 2017. MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141705
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Cheongsoo…[et al.]. MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1141705
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Cheongsoo& Park, Eun-Hye& Kang, Jongeun& Zaheer, Javeria& Lee, Hee Gu& Lee, Chul-Ho…[et al.]. MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141705
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141705
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر