MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI
Joint Authors
Chang, Kiyuk
Hong, Kwan-Su
Park, Cheongsoo
Park, Eun-Hye
Kang, Jongeun
Zaheer, Javeria
Lee, Hee Gu
Lee, Chul-Ho
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We evaluated the relationship between myocardial infarct size and inflammatory response using cardiac magnetic resonance imaging (CMR) in an acute myocardial infarction (AMI) mouse model.
Myocardial infarction (MI) was induced in 14 mice by permanent ligation of the left anterior descending artery.
Late gadolinium enhancement (LGE), manganese-enhanced MRI (MEMRI), and magnetofluorescent nanoparticle MRI (MNP-MRI) were performed 1, 2, and 3 days after MI, respectively.
The size of the enhanced lesion was quantitatively determined using Otsu’s thresholding method in area-based and sector-based approaches and was compared statistically.
Linear correlation between the enhanced lesion sizes was evaluated by Pearson’s correlation coefficients.
Differences were compared using Bland-Altman analysis.
The size of the inflammatory area determined by MNP-MRI (57.1 ± 10.1%) was significantly larger than that of the infarct area measured by LGE (40.8 ± 11.7%, P<0.0001) and MEMRI (44.1 ± 14.9%, P<0.0001).
There were significant correlations between the sizes of the infarct and inflammatory lesions (MNP-MRI versus LGE: r=0.3418, P=0.0099; MNP-MRI versus MEMRI: r=0.4764, P=0.0002).
MNP-MRI provides information about inflammatory responses in a mouse model of AMI.
Thus, MNP-MRI associated with LGE and MEMRI may play an important role in monitoring the disease progression in MI.
American Psychological Association (APA)
Park, Cheongsoo& Park, Eun-Hye& Kang, Jongeun& Zaheer, Javeria& Lee, Hee Gu& Lee, Chul-Ho…[et al.]. 2017. MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141705
Modern Language Association (MLA)
Park, Cheongsoo…[et al.]. MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1141705
American Medical Association (AMA)
Park, Cheongsoo& Park, Eun-Hye& Kang, Jongeun& Zaheer, Javeria& Lee, Hee Gu& Lee, Chul-Ho…[et al.]. MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141705