The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging
المؤلفون المشاركون
Berkova, Zuzana
Kriz, Jan
Fabryova, Eva
Kosinova, Lucie
Gálisová, Andrea
Sticová, Eva
Jirátová, Markéta
Herynek, Vít
Hájek, Milan
Jirák, Daniel
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Subcutaneously implanted polymeric scaffolds represent an alternative transplantation site for pancreatic islets (PIs) with the option of vascularisation enhancement by mesenchymal stem cells (MSC).
Nevertheless, a proper timing of the transplantation steps is crucial.
In this study, scaffolds supplemented with plastic rods were implanted into diabetic rats and two timing schemes for subsequent transplantation of bioluminescent PIs (4 or 7 days after rod removal) were examined by multimodal imaging.
The cavities were left to heal spontaneously or with 10 million injected MSCs.
Morphological and vascularisation changes were examined by MRI, while the localisation and viability of transplanted islets were monitored by bioluminescence imaging.
The results show that PIs transplanted 4 days after rod removal showed the higher optical signal and vascularisation compared to transplantation after 7 days.
MSCs slightly improved vascularisation of the graft but hindered therapeutic efficiency of PIs.
Long-term glycaemia normalisation (4 months) was attained in 80% of animals.
In summary, multimodal imaging confirmed the long-term survival and function of transplanted PIs in the devices.
The best outcome was reached with PIs transplanted on day 4 after rod removal and therefore the suggested protocol holds a potential for further applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gálisová, Andrea& Fabryova, Eva& Sticová, Eva& Kosinova, Lucie& Jirátová, Markéta& Herynek, Vít…[et al.]. 2017. The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1141778
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gálisová, Andrea…[et al.]. The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1141778
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gálisová, Andrea& Fabryova, Eva& Sticová, Eva& Kosinova, Lucie& Jirátová, Markéta& Herynek, Vít…[et al.]. The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1141778
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141778
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر