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Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging
المؤلفون المشاركون
Liu, Qingyao
Zhang, Yongxue
Lan, Xiaoli
Hu, Fan
Yin, Lianglan
Zhang, Yingying
Xia, Xiaotian
Qin, Chunxia
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Introduction.
Radiolabeled gold nanoparticles play an important role in biomedical application.
The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrin αvβ3-expressing tumors.
Methods.
HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of bare GNRs for better biocompatibility, and c(RGDfK) peptides were conjugated onto the carboxyl terminal of GNR-PEG-COOH via EDC/NHS coupling reactions.
The nanoconjugate was characterized, and 131I was directly tagged on the surface of GNRs via AuI bonds for SPECT/CT imaging.
We preliminarily studied the characteristics of the probe and its feasibility for tumor-targeting SPECT/CT imaging.
Results.
The [131I]GNR-PEG-cRGD probe was prepared in a simple and rapid manner and was stable in both PBS and fetal bovine serum.
It targeted selectively and could be taken up by tumor cells mainly via integrin αvβ3-receptor-mediated endocytosis.
In vivo imaging, biodistribution, and autoradiography results showed evident tumor uptake in integrin αvβ3-expressing tumors.
Conclusions.
These promising results showed that this smart nanoprobe can be used for angiogenesis-targeted SPECT/CT imaging.
Furthermore, the nanoprobe possesses a remarkable capacity for highly efficient photothermal conversion in the near-infrared region, suggesting its potential as a multifunctional theranostic agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yingying& Zhang, Yongxue& Yin, Lianglan& Xia, Xiaotian& Hu, Fan& Liu, Qingyao…[et al.]. 2017. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yingying…[et al.]. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yingying& Zhang, Yongxue& Yin, Lianglan& Xia, Xiaotian& Hu, Fan& Liu, Qingyao…[et al.]. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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