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Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging
Joint Authors
Liu, Qingyao
Zhang, Yongxue
Lan, Xiaoli
Hu, Fan
Yin, Lianglan
Zhang, Yingying
Xia, Xiaotian
Qin, Chunxia
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Radiolabeled gold nanoparticles play an important role in biomedical application.
The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrin αvβ3-expressing tumors.
Methods.
HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of bare GNRs for better biocompatibility, and c(RGDfK) peptides were conjugated onto the carboxyl terminal of GNR-PEG-COOH via EDC/NHS coupling reactions.
The nanoconjugate was characterized, and 131I was directly tagged on the surface of GNRs via AuI bonds for SPECT/CT imaging.
We preliminarily studied the characteristics of the probe and its feasibility for tumor-targeting SPECT/CT imaging.
Results.
The [131I]GNR-PEG-cRGD probe was prepared in a simple and rapid manner and was stable in both PBS and fetal bovine serum.
It targeted selectively and could be taken up by tumor cells mainly via integrin αvβ3-receptor-mediated endocytosis.
In vivo imaging, biodistribution, and autoradiography results showed evident tumor uptake in integrin αvβ3-expressing tumors.
Conclusions.
These promising results showed that this smart nanoprobe can be used for angiogenesis-targeted SPECT/CT imaging.
Furthermore, the nanoprobe possesses a remarkable capacity for highly efficient photothermal conversion in the near-infrared region, suggesting its potential as a multifunctional theranostic agent.
American Psychological Association (APA)
Zhang, Yingying& Zhang, Yongxue& Yin, Lianglan& Xia, Xiaotian& Hu, Fan& Liu, Qingyao…[et al.]. 2017. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141800
Modern Language Association (MLA)
Zhang, Yingying…[et al.]. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141800
American Medical Association (AMA)
Zhang, Yingying& Zhang, Yongxue& Yin, Lianglan& Xia, Xiaotian& Hu, Fan& Liu, Qingyao…[et al.]. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141800