Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes
المؤلفون المشاركون
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In our study, we aimed to extract dysregulated pathways in human monocytes infected by Listeria monocytogenes (LM) based on pathway interaction network (PIN) which presented the functional dependency between pathways.
After genes were aligned to the pathways, principal component analysis (PCA) was used to calculate the pathway activity for each pathway, followed by detecting seed pathway.
A PIN was constructed based on gene expression profile, protein-protein interactions (PPIs), and cellular pathways.
Identifying dysregulated pathways from the PIN was performed relying on seed pathway and classification accuracy.
To evaluate whether the PIN method was feasible or not, we compared the introduced method with standard network centrality measures.
The pathway of RNA polymerase II pretranscription events was selected as the seed pathway.
Taking this seed pathway as start, one pathway set (9 dysregulated pathways) with AUC score of 1.00 was identified.
Among the 5 hub pathways obtained using standard network centrality measures, 4 pathways were the common ones between the two methods.
RNA polymerase II transcription and DNA replication owned a higher number of pathway genes and DEGs.
These dysregulated pathways work together to influence the progression of LM infection, and they will be available as biomarkers to diagnose LM infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Wufeng& Zhou, Yuhan& Li, Hao. 2017. Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142060
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Wufeng…[et al.]. Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1142060
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Wufeng& Zhou, Yuhan& Li, Hao. Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142060
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142060
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر