Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In our study, we aimed to extract dysregulated pathways in human monocytes infected by Listeria monocytogenes (LM) based on pathway interaction network (PIN) which presented the functional dependency between pathways.
After genes were aligned to the pathways, principal component analysis (PCA) was used to calculate the pathway activity for each pathway, followed by detecting seed pathway.
A PIN was constructed based on gene expression profile, protein-protein interactions (PPIs), and cellular pathways.
Identifying dysregulated pathways from the PIN was performed relying on seed pathway and classification accuracy.
To evaluate whether the PIN method was feasible or not, we compared the introduced method with standard network centrality measures.
The pathway of RNA polymerase II pretranscription events was selected as the seed pathway.
Taking this seed pathway as start, one pathway set (9 dysregulated pathways) with AUC score of 1.00 was identified.
Among the 5 hub pathways obtained using standard network centrality measures, 4 pathways were the common ones between the two methods.
RNA polymerase II transcription and DNA replication owned a higher number of pathway genes and DEGs.
These dysregulated pathways work together to influence the progression of LM infection, and they will be available as biomarkers to diagnose LM infection.
American Psychological Association (APA)
Fan, Wufeng& Zhou, Yuhan& Li, Hao. 2017. Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142060
Modern Language Association (MLA)
Fan, Wufeng…[et al.]. Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1142060
American Medical Association (AMA)
Fan, Wufeng& Zhou, Yuhan& Li, Hao. Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142060