Block-Constraint Laplacian-Regularized Low-Rank Representation and Its Application for Cancer Sample Clustering Based on Integrated TCGA Data
المؤلفون المشاركون
Zheng, Chun-Hou
Liu, Jin-Xing
Wang, Juan
Dai, Ling-Yun
Lu, Cong-Hai
Kong, Xiang-Zhen
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Low-Rank Representation (LRR) is a powerful subspace clustering method because of its successful learning of low-dimensional subspace of data.
With the breakthrough of “OMics” technology, many LRR-based methods have been proposed and used to cancer clustering based on gene expression data.
Moreover, studies have shown that besides gene expression data, some other genomic data in TCGA also contain important information for cancer research.
Therefore, these genomic data can be integrated as a comprehensive feature source for cancer clustering.
How to establish an effective clustering model for comprehensive analysis of integrated TCGA data has become a key issue.
In this paper, we develop the traditional LRR method and propose a novel method named Block-constraint Laplacian-Regularized Low-Rank Representation (BLLRR) to model multigenome data for cancer sample clustering.
The proposed method is dedicated to extracting more abundant subspace structure information from multiple genomic data to improve the accuracy of cancer sample clustering.
Considering the heterogeneity of different genome data, we introduce the block-constraint idea into our method.
In BLLRR decomposition, we treat each genome data as a data block and impose different constraints on different data blocks.
In addition, graph Laplacian is also introduced into our method to better learn the topological structure of data by preserving the local geometric information.
The experiments demonstrate that the BLLRR method can effectively analyze integrated TCGA data and extract more subspace structure information from multigenome data.
It is a reliable and efficient clustering algorithm for cancer sample clustering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Juan& Liu, Jin-Xing& Zheng, Chun-Hou& Lu, Cong-Hai& Dai, Ling-Yun& Kong, Xiang-Zhen. 2020. Block-Constraint Laplacian-Regularized Low-Rank Representation and Its Application for Cancer Sample Clustering Based on Integrated TCGA Data. Complexity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1142114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Juan…[et al.]. Block-Constraint Laplacian-Regularized Low-Rank Representation and Its Application for Cancer Sample Clustering Based on Integrated TCGA Data. Complexity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1142114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Juan& Liu, Jin-Xing& Zheng, Chun-Hou& Lu, Cong-Hai& Dai, Ling-Yun& Kong, Xiang-Zhen. Block-Constraint Laplacian-Regularized Low-Rank Representation and Its Application for Cancer Sample Clustering Based on Integrated TCGA Data. Complexity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1142114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر