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A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively
المؤلفون المشاركون
Desai, Aakash
Delasos, Lukas
Lopetegui Lia, Nerea
Kethireddy, Nikhila
Ray, Carolyn
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The advent of checkpoint inhibitor therapy in medical oncology has led to an increase in hospitalizations for immune-related adverse effects.
Severe colitis has been reported in approximately 5% of patients treated with cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) inhibitors, such as ipilimumab.
Standard management for those with severe colitis includes administration of systemic corticosteroids with the reservation of antitumor necrosis factor (anti-TNF) therapy, such as infliximab, if there has been no improvement.
Rarely, immunotherapy-induced colitis can become life-threatening and result in bowel perforation requiring surgical intervention.
Yet, there are no specific recommendations for medical management following colectomy in these situations.
In cases of severe colitis from Crohn’s disease, postoperative treatment with infliximab has been found to be safe when administered shortly after intestinal resection.
However, there remains limited data to support administration of infliximab following bowel perforation due to immunotherapy-induced colitis.
Our case illustrates management of a severe adverse reaction to checkpoint inhibitor therapy and the need to further evaluate the role of infliximab postoperatively in patients who develop colitis complicated by bowel perforation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Delasos, Lukas& Desai, Aakash& Lopetegui Lia, Nerea& Kethireddy, Nikhila& Ray, Carolyn. 2019. A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1142189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Delasos, Lukas…[et al.]. A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1142189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Delasos, Lukas& Desai, Aakash& Lopetegui Lia, Nerea& Kethireddy, Nikhila& Ray, Carolyn. A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1142189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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