A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively
Joint Authors
Desai, Aakash
Delasos, Lukas
Lopetegui Lia, Nerea
Kethireddy, Nikhila
Ray, Carolyn
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The advent of checkpoint inhibitor therapy in medical oncology has led to an increase in hospitalizations for immune-related adverse effects.
Severe colitis has been reported in approximately 5% of patients treated with cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) inhibitors, such as ipilimumab.
Standard management for those with severe colitis includes administration of systemic corticosteroids with the reservation of antitumor necrosis factor (anti-TNF) therapy, such as infliximab, if there has been no improvement.
Rarely, immunotherapy-induced colitis can become life-threatening and result in bowel perforation requiring surgical intervention.
Yet, there are no specific recommendations for medical management following colectomy in these situations.
In cases of severe colitis from Crohn’s disease, postoperative treatment with infliximab has been found to be safe when administered shortly after intestinal resection.
However, there remains limited data to support administration of infliximab following bowel perforation due to immunotherapy-induced colitis.
Our case illustrates management of a severe adverse reaction to checkpoint inhibitor therapy and the need to further evaluate the role of infliximab postoperatively in patients who develop colitis complicated by bowel perforation.
American Psychological Association (APA)
Delasos, Lukas& Desai, Aakash& Lopetegui Lia, Nerea& Kethireddy, Nikhila& Ray, Carolyn. 2019. A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1142189
Modern Language Association (MLA)
Delasos, Lukas…[et al.]. A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1142189
American Medical Association (AMA)
Delasos, Lukas& Desai, Aakash& Lopetegui Lia, Nerea& Kethireddy, Nikhila& Ray, Carolyn. A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1142189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142189