Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis
المؤلف
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We aimed to identify risk pathways for postmenopausal osteoporosis (PMOP) via establishing an microRNAs- (miRNA-) regulated pathway network (MRPN).
Firstly, we identified differential pathways through calculating gene- and pathway-level statistics based on the accumulated normal samples using the individual pathway aberrance score (iPAS).
Significant pathways based on differentially expressed genes (DEGs) using DAVID were extracted, followed by identifying the common pathways between iPAS and DAVID methods.
Next, miRNAs prediction was implemented via calculating TargetScore values with precomputed input (log fold change (FC), TargetScan context score (TSCS), and probabilities of conserved targeting (PCT)).
An MRPN construction was constructed using the common genes in the common pathways and the predicted miRNAs.
Using false discovery rate (FDR) < 0.05, 279 differential pathways were identified.
Using the criteria of FDR < 0.05 and logFC≥2, 39 DEGs were retrieved, and these DEGs were enriched in 64 significant pathways identified by DAVID.
Overall, 27 pathways were the common ones between two methods.
Importantly, MAPK signaling pathway and PI3K-Akt signaling pathway were the first and second significantly enriched ones, respectively.
These 27 common pathways separated PMOP from controls with the accuracy of 0.912.
MAPK signaling pathway and PI3K/Akt signaling pathway might play crucial roles in PMOP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shao, Min. 2017. Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shao, Min. Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1142422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shao, Min. Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر