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Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We aimed to identify risk pathways for postmenopausal osteoporosis (PMOP) via establishing an microRNAs- (miRNA-) regulated pathway network (MRPN).
Firstly, we identified differential pathways through calculating gene- and pathway-level statistics based on the accumulated normal samples using the individual pathway aberrance score (iPAS).
Significant pathways based on differentially expressed genes (DEGs) using DAVID were extracted, followed by identifying the common pathways between iPAS and DAVID methods.
Next, miRNAs prediction was implemented via calculating TargetScore values with precomputed input (log fold change (FC), TargetScan context score (TSCS), and probabilities of conserved targeting (PCT)).
An MRPN construction was constructed using the common genes in the common pathways and the predicted miRNAs.
Using false discovery rate (FDR) < 0.05, 279 differential pathways were identified.
Using the criteria of FDR < 0.05 and logFC≥2, 39 DEGs were retrieved, and these DEGs were enriched in 64 significant pathways identified by DAVID.
Overall, 27 pathways were the common ones between two methods.
Importantly, MAPK signaling pathway and PI3K-Akt signaling pathway were the first and second significantly enriched ones, respectively.
These 27 common pathways separated PMOP from controls with the accuracy of 0.912.
MAPK signaling pathway and PI3K/Akt signaling pathway might play crucial roles in PMOP.
American Psychological Association (APA)
Shao, Min. 2017. Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142422
Modern Language Association (MLA)
Shao, Min. Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1142422
American Medical Association (AMA)
Shao, Min. Construction of an miRNA-Regulated Pathway Network Reveals Candidate Biomarkers for Postmenopausal Osteoporosis. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142422