Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness
المؤلفون المشاركون
Lauria, Mario
Marchetti, Luca
Siena, Emilio
Maffione, Denise
Pacchiani, Nicola
Medini, Duccio
Priami, Corrado
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Systems biology has been recently applied to vaccinology to better understand immunological responses to the influenza vaccine.
Particular attention has been paid to the identification of early signatures capable of predicting vaccine immunogenicity.
Building from previous studies, we employed a recently established algorithm for signature-based clustering of expression profiles, SCUDO, to provide new insights into why blood-derived transcriptome biomarkers often fail to predict the seroresponse to the influenza virus vaccination.
Specifically, preexisting immunity against one or more vaccine antigens, which was found to negatively affect the seroresponse, was identified as a confounding factor able to decouple early transcriptome from later antibody responses, resulting in the degradation of a biomarker predictive power.
Finally, the broadly accepted definition of seroresponse to influenza virus vaccine, represented by the maximum response across the vaccine-targeted strains, was compared to a composite measure integrating the responses against all strains.
This analysis revealed that composite measures provide a more accurate assessment of the seroresponse to multicomponent influenza vaccines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marchetti, Luca& Siena, Emilio& Lauria, Mario& Maffione, Denise& Pacchiani, Nicola& Priami, Corrado…[et al.]. 2017. Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness. Complexity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marchetti, Luca…[et al.]. Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness. Complexity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1142674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marchetti, Luca& Siena, Emilio& Lauria, Mario& Maffione, Denise& Pacchiani, Nicola& Priami, Corrado…[et al.]. Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness. Complexity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر