Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis
المؤلفون المشاركون
Hua, Liang
Zhou, H.
Zhang, Kun
Fu, JunHong
Zhang, Peijian
Shao, Yeqin
Xu, Sheng
Wang, Jing
Chen, Li
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Histological assessment of glands is one of the major concerns in colon cancer grading.
Considering that poorly differentiated colorectal glands cannot be accurately segmented, we propose an approach for segmentation of glands in colon cancer images, based on the characteristics of lumens and rough gland boundaries.
First, we use a U-net for stain separation to obtain H-stain, E-stain, and background stain intensity maps.
Subsequently, epithelial nucleus is identified on the histopathology images, and the lumen segmentation is performed on the background intensity map.
Then, we use the axis of least inertia-based similar triangles as the spatial characteristics of lumens and epithelial nucleus, and a triangle membership is used to select glandular contour candidates from epithelial nucleus.
By connecting lumens and epithelial nucleus, more accurate gland segmentation is performed based on the rough gland boundary.
The proposed stain separation approach is unsupervised, and the stain separation makes the category information contained in the H&E image easy to identify and deal with the uneven stain intensity and the inconspicuous stain difference.
In this project, we use deep learning to achieve stain separation by predicting the stain coefficient.
Under the deep learning framework, we design a stain coefficient interval model to improve the stain generalization performance.
Another innovation is that we propose the combination of the internal lumen contour of adenoma and the outer contour of epithelial cells to obtain a precise gland contour.
We compare the performance of the proposed algorithm against that of several state-of-the-art technologies on publicly available datasets.
The results show that the segmentation approach combining the characteristics of lumens and rough gland boundary has better segmentation accuracy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Kun& Fu, JunHong& Hua, Liang& Zhang, Peijian& Shao, Yeqin& Xu, Sheng…[et al.]. 2020. Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis. Complexity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1142765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Kun…[et al.]. Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis. Complexity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1142765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Kun& Fu, JunHong& Hua, Liang& Zhang, Peijian& Shao, Yeqin& Xu, Sheng…[et al.]. Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis. Complexity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1142765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر