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Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma
المؤلفون المشاركون
Moraitis, Andreas
Ragucci, Enzo
Nguyen, Dat
Lamerson, Michele
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Cushing syndrome (CS), a complex, multisystemic condition resulting from prolonged exposure to cortisol, is frequently associated with nonalcoholic fatty liver disease (NAFLD).
In patients with adrenal adenoma(s) and NAFLD, it is essential to rule out coexisting endocrine disorders like CS, so that the underlying condition can be properly addressed.
We report a case of a 49-year-old woman with a history of hypertension, prediabetes, dyslipidemia, biopsy-confirmed steatohepatitis, and benign adrenal adenoma, who was referred for endocrine work-up for persistent weight gain.
Overt Cushing features were absent.
Biochemical evaluation revealed nonsuppressed cortisol on multiple 1-mg dexamethasone suppression tests, suppressed adrenocorticotropic hormone, and low dehydroepiandrosterone sulfate.
The patient initially declined surgery and was treated with mifepristone, a competitive glucocorticoid receptor antagonist.
In addition to improvements in weight and hypertension, substantial reductions in her liver enzymes were noted, with complete normalization by 20 weeks of therapy.
This case suggests that autonomous cortisol secretion from adrenal adenoma(s) could contribute to the metabolic and liver abnormalities in patients with NAFLD.
In conclusion, successful management of CS with mifepristone led to marked improvement in the liver enzymes of a patient with long-standing NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ragucci, Enzo& Nguyen, Dat& Lamerson, Michele& Moraitis, Andreas. 2017. Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. Case Reports in Endocrinology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145128
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ragucci, Enzo…[et al.]. Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. Case Reports in Endocrinology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1145128
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ragucci, Enzo& Nguyen, Dat& Lamerson, Michele& Moraitis, Andreas. Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. Case Reports in Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145128
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145128
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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