Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma
Joint Authors
Moraitis, Andreas
Ragucci, Enzo
Nguyen, Dat
Lamerson, Michele
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cushing syndrome (CS), a complex, multisystemic condition resulting from prolonged exposure to cortisol, is frequently associated with nonalcoholic fatty liver disease (NAFLD).
In patients with adrenal adenoma(s) and NAFLD, it is essential to rule out coexisting endocrine disorders like CS, so that the underlying condition can be properly addressed.
We report a case of a 49-year-old woman with a history of hypertension, prediabetes, dyslipidemia, biopsy-confirmed steatohepatitis, and benign adrenal adenoma, who was referred for endocrine work-up for persistent weight gain.
Overt Cushing features were absent.
Biochemical evaluation revealed nonsuppressed cortisol on multiple 1-mg dexamethasone suppression tests, suppressed adrenocorticotropic hormone, and low dehydroepiandrosterone sulfate.
The patient initially declined surgery and was treated with mifepristone, a competitive glucocorticoid receptor antagonist.
In addition to improvements in weight and hypertension, substantial reductions in her liver enzymes were noted, with complete normalization by 20 weeks of therapy.
This case suggests that autonomous cortisol secretion from adrenal adenoma(s) could contribute to the metabolic and liver abnormalities in patients with NAFLD.
In conclusion, successful management of CS with mifepristone led to marked improvement in the liver enzymes of a patient with long-standing NAFLD.
American Psychological Association (APA)
Ragucci, Enzo& Nguyen, Dat& Lamerson, Michele& Moraitis, Andreas. 2017. Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. Case Reports in Endocrinology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145128
Modern Language Association (MLA)
Ragucci, Enzo…[et al.]. Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. Case Reports in Endocrinology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1145128
American Medical Association (AMA)
Ragucci, Enzo& Nguyen, Dat& Lamerson, Michele& Moraitis, Andreas. Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. Case Reports in Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145128