Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer
المؤلفون المشاركون
Takeda, Katsushi
Kimura, Ryosuke
Nishigaki, Nobuhiro
Sato, Shinya
Okamoto, Asami
Watanabe, Kumiko
Yasui, Sachie
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Humoral hypercalcemia of malignancy (HHM) is caused by the oversecretion of parathyroid hormone-related peptide (PTHrP) from malignant tumors.
Although any tumor may cause HHM, that induced by intrahepatic cholangiocarcinoma (ICC) or gastric cancer (GC) is rare.
We report here a 74-year-old male who displayed HHM with both ICC and GC and showed an elevated serum PTHrP level.
Treatment of the hypercalcemia with saline, furosemide, elcatonin, and zoledronic acid corrected his serum calcium level and improved symptoms.
Because treatment of ICC should precede that of GC, we chose chemotherapy with cisplatin (CDDP) and gemcitabine (GEM).
Chemotherapy reduced the size of the ICC and decreased the serum PTHrP level.
One year after diagnosis, the patient was alive in the face of a poor prognosis for an ICC that produced PTHrP.
Immunohistochemical staining for PTHrP was positive for the ICC and negative for the GC, leading us to believe that the cause of the HHM was a PTHrP-secreting ICC.
In conclusion, immunohistochemical staining for PTHrP may be useful in discovering the cause of HHM in the case of two cancers accompanied by an elevated serum PHTrP level.
Chemotherapy with CDDP and GEM may be the most appropriate treatment for a PTHrP-secreting ICC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takeda, Katsushi& Kimura, Ryosuke& Nishigaki, Nobuhiro& Sato, Shinya& Okamoto, Asami& Watanabe, Kumiko…[et al.]. 2017. Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer. Case Reports in Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145146
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takeda, Katsushi…[et al.]. Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer. Case Reports in Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1145146
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takeda, Katsushi& Kimura, Ryosuke& Nishigaki, Nobuhiro& Sato, Shinya& Okamoto, Asami& Watanabe, Kumiko…[et al.]. Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer. Case Reports in Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145146
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145146
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر