Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer
Joint Authors
Takeda, Katsushi
Kimura, Ryosuke
Nishigaki, Nobuhiro
Sato, Shinya
Okamoto, Asami
Watanabe, Kumiko
Yasui, Sachie
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Humoral hypercalcemia of malignancy (HHM) is caused by the oversecretion of parathyroid hormone-related peptide (PTHrP) from malignant tumors.
Although any tumor may cause HHM, that induced by intrahepatic cholangiocarcinoma (ICC) or gastric cancer (GC) is rare.
We report here a 74-year-old male who displayed HHM with both ICC and GC and showed an elevated serum PTHrP level.
Treatment of the hypercalcemia with saline, furosemide, elcatonin, and zoledronic acid corrected his serum calcium level and improved symptoms.
Because treatment of ICC should precede that of GC, we chose chemotherapy with cisplatin (CDDP) and gemcitabine (GEM).
Chemotherapy reduced the size of the ICC and decreased the serum PTHrP level.
One year after diagnosis, the patient was alive in the face of a poor prognosis for an ICC that produced PTHrP.
Immunohistochemical staining for PTHrP was positive for the ICC and negative for the GC, leading us to believe that the cause of the HHM was a PTHrP-secreting ICC.
In conclusion, immunohistochemical staining for PTHrP may be useful in discovering the cause of HHM in the case of two cancers accompanied by an elevated serum PHTrP level.
Chemotherapy with CDDP and GEM may be the most appropriate treatment for a PTHrP-secreting ICC.
American Psychological Association (APA)
Takeda, Katsushi& Kimura, Ryosuke& Nishigaki, Nobuhiro& Sato, Shinya& Okamoto, Asami& Watanabe, Kumiko…[et al.]. 2017. Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer. Case Reports in Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145146
Modern Language Association (MLA)
Takeda, Katsushi…[et al.]. Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer. Case Reports in Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1145146
American Medical Association (AMA)
Takeda, Katsushi& Kimura, Ryosuke& Nishigaki, Nobuhiro& Sato, Shinya& Okamoto, Asami& Watanabe, Kumiko…[et al.]. Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer. Case Reports in Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1145146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145146