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Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic
المؤلفون المشاركون
Ono, Yuko
Ono, Nozomi
Shinohara, Kazuaki
المصدر
Case Reports in Emergency Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-07
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Naphazoline is a peripheral α2-adrenergic receptor agonist commonly used as a topical decongestant.
In Japan, over-the-counter antiseptics often contain naphazoline to effect local hemostasis.
We present the first case involving the development of hypercoagulopathy, with kidney and liver dysfunction, following a naphazoline overdose.
A 22-year-old Japanese woman with a history of depression ingested 160 mL of a commercially available antiseptic containing 0.1% naphazoline.
Three days later, she was brought to the emergency department because of general fatigue, nausea, and vomiting.
Physical examination revealed cool, pale extremities.
Laboratory data showed evidence of severe kidney and liver dysfunction (creatinine, 9.2 mg/dL; alanine aminotransferase, 2948 IU/L), hypercoagulation (D-dimers, 58.3 μg/mL), and thrombocytopenia (platelet count, 90,000/μL).
After infusion of normal saline, intravenous administration of alprostadil, and hemodiafiltration, her organ function completely recovered.
Because both the kidney and liver express α2-adrenergic receptors, their failure was likely associated with naphazoline overdose-induced hypoperfusion.
The most plausible causes of hypercoagulation are peripheral low perfusion and subsequent microthrombus formation.
This case illustrates that severe organ dysfunction can occur following over-the-counter antiseptic ingestion and serves as a caution for both drug manufacturers and healthcare professionals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ono, Yuko& Ono, Nozomi& Shinohara, Kazuaki. 2017. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Reports in Emergency Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145219
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ono, Yuko…[et al.]. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Reports in Emergency Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1145219
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ono, Yuko& Ono, Nozomi& Shinohara, Kazuaki. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Reports in Emergency Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145219
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145219
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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