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Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic
Joint Authors
Ono, Yuko
Ono, Nozomi
Shinohara, Kazuaki
Source
Case Reports in Emergency Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Naphazoline is a peripheral α2-adrenergic receptor agonist commonly used as a topical decongestant.
In Japan, over-the-counter antiseptics often contain naphazoline to effect local hemostasis.
We present the first case involving the development of hypercoagulopathy, with kidney and liver dysfunction, following a naphazoline overdose.
A 22-year-old Japanese woman with a history of depression ingested 160 mL of a commercially available antiseptic containing 0.1% naphazoline.
Three days later, she was brought to the emergency department because of general fatigue, nausea, and vomiting.
Physical examination revealed cool, pale extremities.
Laboratory data showed evidence of severe kidney and liver dysfunction (creatinine, 9.2 mg/dL; alanine aminotransferase, 2948 IU/L), hypercoagulation (D-dimers, 58.3 μg/mL), and thrombocytopenia (platelet count, 90,000/μL).
After infusion of normal saline, intravenous administration of alprostadil, and hemodiafiltration, her organ function completely recovered.
Because both the kidney and liver express α2-adrenergic receptors, their failure was likely associated with naphazoline overdose-induced hypoperfusion.
The most plausible causes of hypercoagulation are peripheral low perfusion and subsequent microthrombus formation.
This case illustrates that severe organ dysfunction can occur following over-the-counter antiseptic ingestion and serves as a caution for both drug manufacturers and healthcare professionals.
American Psychological Association (APA)
Ono, Yuko& Ono, Nozomi& Shinohara, Kazuaki. 2017. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Reports in Emergency Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145219
Modern Language Association (MLA)
Ono, Yuko…[et al.]. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Reports in Emergency Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1145219
American Medical Association (AMA)
Ono, Yuko& Ono, Nozomi& Shinohara, Kazuaki. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Reports in Emergency Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145219