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Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease
المؤلفون المشاركون
Ochi, Fumihiro
Eguchi, Mariko
Ishii, Eiichi
Moritani, Kyoko
Miyawaki, Reiji
Tokuda, Kiriko
Eguchi-Ishimae, Minenori
Tauchi, Hisamichi
Nagai, Kozo
المصدر
Case Reports in Transplantation
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The authors describe the high effectiveness of human mesenchymal stem cell (hMSC) therapy to treat steroid-refractory gastrointestinal acute graft-versus-host Disease (aGVHD) in a 15-year-old boy with acute lymphoblastic leukemia (ALL).
He received allogeneic hematopoietic stem cell transplantation due to high-risk hypodiploid ALL.
Around the time of engraftment, he developed severe diarrhea following high-grade fever and erythema.
Although methylprednisolone pulse therapy was added to tacrolimus and mycophenolate mofetil, diarrhea progressed up to 5000~6000 ml/day and brought about hypocalcemia, hypoalbuminemia, and edema.
Daily fresh frozen plasma (FFP), albumin, and calcium replacements were required to maintain blood circulation.
After aGVHD was confirmed by colonoscopic biopsy, MSC therapy was administered.
The patient received 8 biweekly intravenous infusions of 2×106 hMSCs/kg for 4 weeks, after which additional 4 weekly infusions were performed.
A few weeks after initiation, diarrhea gradually resolved, and at the eighth dose of hMSC, lab data improved without replacements.
MSC therapy successfully treated steroid-refractory gastrointestinal GVHD without complications.
Despite life-threatening diarrhea, the regeneration potential of children and adolescents undergoing SMC therapy successfully supports restoration of gastrointestinal damage.
Even with its high treatment costs, SMC therapy should be proactively considered in cases where young patients suffer from severe gastrointestinal GVHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moritani, Kyoko& Miyawaki, Reiji& Tokuda, Kiriko& Ochi, Fumihiro& Eguchi-Ishimae, Minenori& Tauchi, Hisamichi…[et al.]. 2019. Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. Case Reports in Transplantation،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1145255
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moritani, Kyoko…[et al.]. Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. Case Reports in Transplantation No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1145255
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moritani, Kyoko& Miyawaki, Reiji& Tokuda, Kiriko& Ochi, Fumihiro& Eguchi-Ishimae, Minenori& Tauchi, Hisamichi…[et al.]. Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. Case Reports in Transplantation. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1145255
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145255
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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