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Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease
Joint Authors
Ochi, Fumihiro
Eguchi, Mariko
Ishii, Eiichi
Moritani, Kyoko
Miyawaki, Reiji
Tokuda, Kiriko
Eguchi-Ishimae, Minenori
Tauchi, Hisamichi
Nagai, Kozo
Source
Case Reports in Transplantation
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The authors describe the high effectiveness of human mesenchymal stem cell (hMSC) therapy to treat steroid-refractory gastrointestinal acute graft-versus-host Disease (aGVHD) in a 15-year-old boy with acute lymphoblastic leukemia (ALL).
He received allogeneic hematopoietic stem cell transplantation due to high-risk hypodiploid ALL.
Around the time of engraftment, he developed severe diarrhea following high-grade fever and erythema.
Although methylprednisolone pulse therapy was added to tacrolimus and mycophenolate mofetil, diarrhea progressed up to 5000~6000 ml/day and brought about hypocalcemia, hypoalbuminemia, and edema.
Daily fresh frozen plasma (FFP), albumin, and calcium replacements were required to maintain blood circulation.
After aGVHD was confirmed by colonoscopic biopsy, MSC therapy was administered.
The patient received 8 biweekly intravenous infusions of 2×106 hMSCs/kg for 4 weeks, after which additional 4 weekly infusions were performed.
A few weeks after initiation, diarrhea gradually resolved, and at the eighth dose of hMSC, lab data improved without replacements.
MSC therapy successfully treated steroid-refractory gastrointestinal GVHD without complications.
Despite life-threatening diarrhea, the regeneration potential of children and adolescents undergoing SMC therapy successfully supports restoration of gastrointestinal damage.
Even with its high treatment costs, SMC therapy should be proactively considered in cases where young patients suffer from severe gastrointestinal GVHD.
American Psychological Association (APA)
Moritani, Kyoko& Miyawaki, Reiji& Tokuda, Kiriko& Ochi, Fumihiro& Eguchi-Ishimae, Minenori& Tauchi, Hisamichi…[et al.]. 2019. Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. Case Reports in Transplantation،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1145255
Modern Language Association (MLA)
Moritani, Kyoko…[et al.]. Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. Case Reports in Transplantation No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1145255
American Medical Association (AMA)
Moritani, Kyoko& Miyawaki, Reiji& Tokuda, Kiriko& Ochi, Fumihiro& Eguchi-Ishimae, Minenori& Tauchi, Hisamichi…[et al.]. Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. Case Reports in Transplantation. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1145255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145255