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An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma
المؤلفون المشاركون
Konopleva, Marina
Kadia, Tapan
Boddu, Prajwal
Tang, Guilin
Kanagal-Shamanna, Rashmi
Thakral, Beenu
Jain, Nitin
Jabbour, Elias
Yin, C. Cameron
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-18
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
While rare, cases of isolated extramedullary disease of B-cell Lymphoblastic Lymphoma (B-LBL) without morphologic bone marrow involvement have been described.
In this report, we illustrate the case of an elderly gentleman who presented with isolated testicular and vertebral LBL involvement but had no morphologic bone marrow involvement.
The initial plan of treatment was to treat along the lines of Philadelphia negative B-ALL/LBL.
During this time, fluorescence in situ hybridization (FISH) and PCR testing for BCR-ABL1 rearrangements were being performed on the marrow specimens as a part of routine diagnostic workup.
While the FISH returned negative, PCR testing unexpectedly detected BCR-ABL1 fusion transcripts at a low level of 0.48%.
Given their presence, we performed FISH for BCR/ABL1 rearrangement in both testicular and L5 vertebral specimens which were 80–90% positive.
He subsequently received rituximab, hyper-CVAD, and dasatinib, along with prophylactic intrathecal prophylactic chemotherapy.
The patient achieved a prolonged remission but eventually relapsed, 4 years later.
Had it not been for this fortuitous discovery, the patient would not have been treated with tyrosine kinase inhibitors.
We emphasize that FISH and PCR testing for BCR-ABL1 rearrangement are integral to arriving at an accurate diagnosis and should be routinely tested on B-LBL biopsy specimens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Boddu, Prajwal& Yin, C. Cameron& Kanagal-Shamanna, Rashmi& Tang, Guilin& Thakral, Beenu& Kadia, Tapan…[et al.]. 2017. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1145782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Boddu, Prajwal…[et al.]. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Reports in Hematology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1145782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Boddu, Prajwal& Yin, C. Cameron& Kanagal-Shamanna, Rashmi& Tang, Guilin& Thakral, Beenu& Kadia, Tapan…[et al.]. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1145782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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